Monday, July 27, 2009

Researchers Find New Way of Reducing Symptoms of Anaphylactic Shock

A team of researchers from the University of Glasgow have pinpointed a molecule (IL-33) which plays a key role in the development of anaphylaxis.

"Our study showed that IL-33 plays a pivotal role in hugely increasing the inflammation experienced during a period of anaphylactic shock and led us to understand how to intervene to reduce its impact.

An anaphylactic shock prompts a massive inflammatory reaction which often is so severe that it constricts breathing. In our study we found that the severity of the shock is linked to the IL-33 molecule, which acts as an amplifier to the inflammatory reaction. This can lead to a fatal constriction of the airway and, ultimately, death.

Our study suggests that patients with the most severe anaphylactic reactions have very high levels of IL33 in their system.

In basic terms, without the IL33 molecule, the allergic reaction experienced would be far less severe, greatly reducing the risk of death."

Read full article here:


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